Research Publications

Aras KK. Sex differences in cardiac electrophysiology: does body size matter?. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1055-H1056. doi: 10.1152/ajpheart.00606.2022. Epub 2022 Oct 28. PubMed PMID: 36306214; PubMed Central PMCID: PMC9678427.
Ernault AC, Verkerk AO, Bayer JD, Aras K, Montañés-Agudo P, Mohan RA, Veldkamp M, Rivaud MR, de Winter R, Kawasaki M, van Amersfoorth SCM, Meulendijks ER, Driessen AHG, Efimov IR, de Groot JR, Coronel R. Secretome of atrial epicardial adipose tissue facilitates reentrant arrhythmias by myocardial remodeling. Heart Rhythm. 2022 Sep;19(9):1461-1470. doi: 10.1016/j.hrthm.2022.05.011. Epub 2022 May 12. PubMed PMID: 35568136; PubMed Central PMCID: PMC9558493.
Yang Z, Zhang L, Aras K, Efimov IR, Adam GC. Hardware-Mappable Cellular Neural Networks for Distributed Wavefront Detection in Next-Generation Cardiac Implants. Adv Intell Syst. 2022 Aug;4(8). doi: 10.1002/aisy.202200032. Epub 2022 May 12. PubMed PMID: 36035592; PubMed Central PMCID: PMC9400456.
Choi YS, Jeong H, Yin RT, Avila R, Pfenniger A, Yoo J, Lee JY, Tzavelis A, Lee YJ, Chen SW, Knight HS, Kim S, Ahn HY, Wickerson G, Vázquez-Guardado A, Higbee-Dempsey E, Russo BA, Napolitano MA, Holleran TJ, Razzak LA, Miniovich AN, Lee G, Geist B, Kim B, Han S, Brennan JA, Aras K, Kwak SS, Kim J, Waters EA, Yang X, Burrell A, San Chun K, Liu C, Wu C, Rwei AY, Spann AN, Banks A, Johnson D, Zhang ZJ, Haney CR, Jin SH, Sahakian AV, Huang Y, Trachiotis GD, Knight BP, Arora RK, Efimov IR, Rogers JA. A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy. Science. 2022 May 27;376(6596):1006-1012. doi: 10.1126/science.abm1703. Epub 2022 May 26. PubMed PMID: 35617386; PubMed Central PMCID: PMC9282941.
Aras K, Gams A, Faye NR, Brennan J, Goldrick K, Li J, Zhong Y, Chiang CH, Smith EH, Poston MD, Chivers J, Hanna P, Mori S, Ajijola OA, Shivkumar K, Hoover DB, Viventi J, Rogers JA, Bernus O, Efimov IR. Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract. Circ Arrhythm Electrophysiol. 2022 Mar;15(3):e010630. doi: 10.1161/CIRCEP.121.010630. Epub 2022 Mar 3. PubMed PMID: 35238622; PubMed Central PMCID: PMC9052172.

Yang Q, Wei T, Yin RT, Wu M, Xu Y, Koo J, Choi YS, Xie Z, Chen SW, Kandela I, Yao S, Deng Y, Avila R, Liu TL, Bai W, Yang Y, Han M, Zhang Q, Haney CR, Benjamin Lee K, Aras K, Wang T, Seo MH, Luan H, Lee SM, Brikha A, Ghoreishi-Haack N, Tran L, Stepien I, Aird F, Waters EA, Yu X, Banks A, Trachiotis GD, Torkelson JM, Huang Y, Kozorovitskiy Y, Efimov IR, Rogers JA. Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues. Nat Mater. 2021 Nov;20(11):1559-1570. doi: 10.1038/s41563-021-01051-x. Epub 2021 Jul 29. PubMed PMID: 34326506; PubMed Central PMCID: PMC8551016.
Kyryachenko S, Georges A, Yu M, Barrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras KK, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N. Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021 Mar 5;128(5):e84-e101. doi: 10.1161/CIRCRESAHA.120.317581. Epub 2021 Jan 28. PubMed PMID: 33508947; PubMed Central PMCID: PMC8316483.

Han M, Chen L, Aras K, Liang C, Chen X, Zhao H, Li K, Faye NR, Sun B, Kim JH, Bai W, Yang Q, Ma Y, Lu W, Song E, Baek JM, Lee Y, Liu C, Model JB, Yang G, Ghaffari R, Huang Y, Efimov IR, Rogers JA. Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery. Nat Biomed Eng. 2020 Oct;4(10):997-1009. doi: 10.1038/s41551-020-00604-w. Epub 2020 Sep 7. PubMed PMID: 32895515; PubMed Central PMCID: PMC8021456.
Handa BS, Li X, Aras KK, Qureshi NA, Mann I, Chowdhury RA, Whinnett ZI, Linton NWF, Lim PB, Kanagaratnam P, Efimov IR, Peters NS, Ng FS. Response by Handa et al to Letter Regarding Article, “Granger Causality-Based Analysis for Classification of Fibrillation Mechanisms and Localization of Rotational Drivers”. Circ Arrhythm Electrophysiol. 2020 Aug;13(8):e008951. doi: 10.1161/CIRCEP.120.008951. Epub 2020 Aug 18. PubMed PMID: 32809880; PubMed Central PMCID: PMC7439311.
Smirnov D, Pikunov A, Syunyaev R, Deviatiiarov R, Gusev O, Aras K, Gams A, Koppel A, Efimov IR. Genetic algorithm-based personalized models of human cardiac action potential. PLoS One. 2020;15(5):e0231695. doi: 10.1371/journal.pone.0231695. eCollection 2020. PubMed PMID: 32392258; PubMed Central PMCID: PMC7213718.
Tate JD, Pilcher TA, Aras KK, Burton BM, MacLeod RS. Validating defibrillation simulation in a human-shaped phantom. Heart Rhythm. 2020 Apr;17(4):661-668. doi: 10.1016/j.hrthm.2019.11.020. Epub 2019 Nov 23. PubMed PMID: 31765807; PubMed Central PMCID: PMC7117986.
Handa BS, Li X, Aras KK, Qureshi NA, Mann I, Chowdhury RA, Whinnett ZI, Linton NWF, Lim PB, Kanagaratnam P, Efimov IR, Peters NS, Ng FS. Granger Causality-Based Analysis for Classification of Fibrillation Mechanisms and Localization of Rotational Drivers. Circ Arrhythm Electrophysiol. 2020 Mar;13(3):e008237. doi: 10.1161/CIRCEP.119.008237. Epub 2020 Feb 16. PubMed PMID: 32064900; PubMed Central PMCID: PMC7069398.
Aras KK, Efimov IR. Irreversible electroporation: Proceed with caution. Heart Rhythm. 2018 Dec;15(12):1880-1881. doi: 10.1016/j.hrthm.2018.07.032. Epub 2018 Jul 29. PubMed PMID: 30063994; PubMed Central PMCID: PMC8025204.
Aras KK, Faye NR, Cathey B, Efimov IR. Critical Volume of Human Myocardium Necessary to Maintain Ventricular Fibrillation. Circ Arrhythm Electrophysiol.2018 Nov;11(11):e006692. doi: 10.1161/CIRCEP.118.006692. PubMed PMID: 30376733; PubMed Central PMCID: PMC7722395.
Burton BM, Aras KK, Good WW, Tate JD, Zenger B, MacLeod RS. A Framework for Image-Based Modeling of Acute Myocardial Ischemia Using Intramurally Recorded Extracellular Potentials. Ann Biomed Eng. 2018 Sep;46(9):1325-1336. doi: 10.1007/s10439-018-2048-0. Epub 2018 May 21. PubMed PMID: 29786776; PubMed Central PMCID: PMC6202115.
Burton BM, Aras KK, Good WW, Tate JD, Zenger B, MacLeod RS. Image-based modeling of acute myocardial ischemia using experimentally derived ischemic zone source representations. J Electrocardiol. 2018 Jul – Aug;51(4):725-733. doi: 10.1016/j.jelectrocard.2018.05.005. Epub 2018 May 18. PubMed PMID: 29997022; PubMed Central PMCID: PMC6050031.
Gloschat C, Aras K, Gupta S, Faye NR, Zhang H, Syunyaev RA, Pryamonosov RA, Rogers J, Kay MW, Efimov IR. RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping. Sci Rep. 2018 Feb 13;8(1):2921. doi: 10.1038/s41598-018-21333-w. PubMed PMID: 29440763; PubMed Central PMCID: PMC5811559.
Rodenhauser A, Good WW, Zenger B, Tate J, Aras K, Burton B, MacLeod RS. PFEIFER: Preprocessing Framework for Electrograms Intermittently Fiducialized from Experimental Recordings. J Open Source Softw. 2018;3(21). doi: 10.21105/joss.00472. PubMed PMID: 30259008; PubMed Central PMCID: PMC6152894.
Aras KK, Kay MW, Efimov IR. Ventricular Fibrillation: Rotors or Foci? Both!. Circ Arrhythm Electrophysiol. 2017 Dec;10(12). doi: 10.1161/CIRCEP.117.006011. PubMed PMID: 29247034; PubMed Central PMCID: PMC8081296.
Gloschat CR, Koppel AC, Aras KK, Brennan JA, Holzem KM, Efimov IR. Arrhythmogenic and metabolic remodelling of failing human heart. J Physiol. 2016 Jul 15;594(14):3963-80. doi: 10.1113/JP271992. Epub 2016 Jun 12. Review. PubMed PMID: 27019074; PubMed Central PMCID: PMC4945707.
Aras K, Burton B, Swenson D, MacLeod R. Spatial organization of acute myocardial ischemia. J Electrocardiol. 2016 May-Jun;49(3):323-36. doi: 10.1016/j.jelectrocard.2016.02.014. Epub 2016 Feb 20. PubMed PMID: 26947437; PubMed Central PMCID: PMC4853261.
Aras K, Good W, Tate J, Burton B, Brooks D, Coll-Font J, Doessel O, Schulze W, Potyagaylo D, Wang L, van Dam P, MacLeod R. Experimental Data and Geometric Analysis Repository-EDGAR. J Electrocardiol. 2015 Nov-Dec;48(6):975-81. doi: 10.1016/j.jelectrocard.2015.08.008. Epub 2015 Aug 4. PubMed PMID: 26320369; PubMed Central PMCID: PMC4624576.
Aras K, Burton B, Swenson D, MacLeod R. Sensitivity of epicardial electrical markers to acute ischemia detection. J Electrocardiol. 2014 Nov-Dec;47(6):836-41. doi: 10.1016/j.jelectrocard.2014.08.014. Epub 2014 Aug 17. PubMed PMID: 25242529; PubMed Central PMCID: PMC4252649.
Tate J, Pilcher T, Aras K, Burton B, MacLeod R. Verification of a Defibrillation Simulation Using Internal Electric Fields in a Human Shaped Phantom.Comput Cardiol (2010). 2014 Sep 7;2014:689-692. PubMed PMID: 26448962; PubMed Central PMCID: PMC4593324.
Aras KK, Shome S, Swenson DJ, Stinstra J, MacLeod RS. Electrographic Response of the Heart to Myocardial Ischemia. Comput Cardiol. 2009;36:105-108. PubMed PMID: 26997739; PubMed Central PMCID: PMC4795003.
Cickovski T, Aras K, Alber MS, Izaguirre JA, Swat M, Glazier JA, Merks RM, Glimm T, Hentschel HG, Newman SA. From Genes to Organisms Via the Cell A Problem-Solving Environment for Multicellular Development. Comput Sci Eng. 2007;9(4):50-60. doi: 10.1109/MCSE.2007.74. PubMed PMID: 19526065; PubMed Central PMCID: PMC2695324.