Tag Archives: featured

Photocurable bioresorbable adhesives as functional intefaces between flexible bioelectronic devices and soft biological tissues

Soft interface materials for joining bioelectronic devices with biological tissues

WHAT IS KNOWN?

  1. Flexible electronic/optoelectronic systems that can physically interface with soft biological tissue surfaces offer revolutionary diagnostic and therapeutic capabilities for various diseases.
  2. However, current approaches to coupling the tissue-device interfaces either through surgical sutures, staples, cuffs, etc., damage the tissue and the devices and often result in adverse immune responses and mechanical instabilities.

WHAT DOES THIS STUDY ADD?

  1. We introduce a functional adhesive bioelectronic-tissue interface material (BTIM), which is mechanically compliant, electrically conductive, and optically transparent. The material can bond to the surface of tissue and the device and provide stable adhesion for several days to months.
  2. We demonstrate the capabilities of this material in live animal models that includes device applications ranging from battery-free optoelectronic systems for deep-brain optogenetics to wireless millimeter-scale pacemakers and flexible multi electrode epicardial arrays.

LINK TO THE ARTICLE

Yang Q, Wei T, Yin RT, Wu M, Xu Y, Koo J, Choi YS, Xie Z, Chen SW, Kandela I, Yao S, Deng Y, Avila R, Liu TL, Bai W, Yang Y, Han M, Zhang Q, Haney CR, Benjamin Lee K, Aras K, Wang T, Seo MH, Luan H, Lee SM, Brikha A, Ghoreishi-Haack N, Tran L, Stepien I, Aird F, Waters EA, Yu X, Banks A, Trachiotis GD, Torkelson JM, Huang Y, Kozorovitskiy Y, Efimov IR, Rogers JA. Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues. Nat Mater. 2021 Jul 29;. doi: 10.1038/s41563-021-01051-x. [Epub ahead of print] PubMed PMID: 34326506.

Chromatin Accessibility of human mitral valves and functional assessment of MVP Risk Loci

rs6723013 is a potential causal variant at IGFBP5/TNS1 MVP-associated locus

WHAT IS KNOWN?

  1. Mitral valve prolapse (MVP) is a common valvopathy that can lead to heart failure and sudden death. However, the causes of MVP development are still poorly understood.
  2. Functional genomic studies are needed to better characterize MVP associated variants and target genes

WHAT DOES THIS STUDY ADD?

  1. We used ATAC-Seq (assay for transposes-accessible chromatin using sequencing) genomic annotation technique in combination with 4C-Seq (circular chromosome conformation capture, coupled to high-throughput sequencing), to describe unprecedented genome-wide chromatin profiles from human pathogenic and non-pathogenic mitral valves.
  2. The experiments also provided evidence for plausible causal variants for rs2641440 at SMG6/SRR locus and rs6723013 at IGFBP2/IGFBP5/TNS1 locus. In addition, we also identified several target genes including SRR, HIC1, and DPH1 at SMG6/SRR locus.

LINK TO THE ARTICLE

Kyryachenko S, Georges A, Yu M, Berrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras K, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N. Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021 Jan 28;. doi: 10.1161/CIRCRESAHA.120.317581. [Epub ahead of print] PubMed PMID: 33508947.

Catheter -integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery

Multimodal multiplexed soft sensors and actuators for minimally invasive surgery

WHAT IS KNOWN?

  1. Catheters are widely used for minimally invasive therapies such as atrial fibrillation ablation, intravascular stents, etc. In addition, they are also used for capturing information during procedures such as measuring temperature, pressure, electrograms etc.
  2. However, these catheters are limited by mechanical rigidity, low spatial densities, single function capability necessitating use of multiple catheters to acquire critical information.

WHAT THIS STUDY ADDS?

  1. We have designed a novel flexible, stretchable and tissue conforming electronics device integrated with a balloon catheter that supports simultaneous high-density spatiotemporal mapping of temperature, pressure, and electrograms.
  2. In addition, our device allows for programmable electrical stimulation, radio frequency ablation and irreversible electroporation.
  3. This novel device, the first of its kind, anywhere in the world, will eventually enable physicians to acquire a rich set of physiological information and complete surgeries and deliver therapies in shorter times than currently possible, with a single instrumented catheter system.

LINK TO THE ARTICLE

Mengdi Han*, Lin Chen*, Kedar Aras*, Cunman Liang, Xuexian Chen, Hangbo Zhao, Kan Li, Ndeye Rokhaya Faye, Bohan Sun, Jae-Hwan Kim, Wubin Bai, Quansan Yang, Yuhang Ma, Wei Lu, Enming Song, Janice Mihyun Baek, Yujin Lee, Clifford Liu, Jeffrey B. Model, Guanjun Yang, Roozbeh Ghaffari, Yonggang Huang, Igor R. Efimov, John A. Rogers. Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery. Nature Biomedical Engineering (2020). https://doi.org/10.1038/s41551-020-00604-w.

K99/R00 Pathway to independence NIH award

Kedar Aras, PhD, has received the National Institutes of Health (NIH) Pathway to Independence Award (K99/R00) as an outstanding postdoctoral researcher to help him complete the needed mentoring and training to transition to an independent, tenure-track faculty position. This is a highly prestigious award offered to promising individuals at early stages in their career who wish to become independent investigators. The award is a five-year grant where two years are spent as a postdoc and three years as an assistant tenure-track faculty member. Dr. Aras will receive $1 Million over the five year period to support his research and for starting his own lab. His research is focused on how cardiac obesity promotes ventricular arrhythmias. Aras is the first individual to receive this award in the Department of Biomedical Engineering at GWU. 

Dr. Aras is currently a postdoctoral scientist training in the lab of Igor Efimov, PhD, Alisann and Terry Collins Professor of Biomedical Engineering. His research project will investigate the role of epicardial adiposity in promoting ventricular arrhythmias. In particular, he will investigate how epicardial adipose tissue paracrine signaling makes obese hearts more vulnerable to arrhythmias. He will also obtain specialized training in bioinformatics and adipocyte tissue biology. The long-term goal of his research is to explore mechanisms of obesity mediated conduction and rhythm disorders using multiscale and multimodal approach as well as develop and validate novel diagnostic tools and strategies for effective therapy of these diseases.

His mentors on this research are: Prof. Igor Efimov (George Washington University), Prof. Keith Crandall (George Washington University), Prof. Rong Li (George Washington University), Prof. Mark Anderson (Johns Hopkins University), Prof. John Rogers (Northwestern University), Prof. Bjorn Knollmann (Vanderbilt University), Prof. Kalyanam Shivkumar (University of California Los Angeles) and Prof. Richard Schuessler (Washington University Saint Louis).