Category Archives: Research Resources

Book Chapter – Advances in Cardiovascular Technology

Advances in Cardiovascular Technology – New Devices and Concepts

Chapter 36 – Innovation in Cardiovascular Bioelectronics

Rose T. Yin, Yeon Sik Choi, Kedar K. Aras, Helen S. Knight, Alana N. Miniovich, and Igor R. Efimov


Advances in materials science have enabled new bioelectronics platforms for novel approaches to medicine. Bioelectronics for disease diagnosis and treatment that were once bulky have become miniaturized and lightweight. The rigid geometries that were previously incompatible with tissues and organs are now flexible and stretchable to conform to organ curvatures. Energy sources dependent on batteries can now harvest energy from mechanical motion, static electricity, light, ultrasound, and electromagnetic fields.

Materials at the tissue – bioelectronics interface inducing significant foreign body responses have been replaced by materials such as hydrogels and graphene that are much more biocompatible. These innovations have enabled the development of bioelectronics for the treatment of cardiovascular diseases, such as monitors, ablation, pacemaker, and implantable cardioverter defibrillator (ICD) therapy.

This portfolio of bioelectronic devices collects high-resolution data across multiple parameters and can deliver the pertinent electrotherapy. The bioelectronic conformal devices serve as the foundation of the medical internet-of-things, which will ultimately improve the accessibility of medicine, the efficiency of the healthcare system, and enhance human health.

Original Research: A Framework for Image-Based Modeling of Acute Myocardial Ischemia Using Intramurally Recorded Extracellular Potentials

My co-authored research article titled – A Framework for Image-Based Modeling of Acute Myocardial Ischemia Using Intramurally Recorded Extracellular Potentials was published in the peer review journal – Annals of Biomedical Engineering. The article is available in print, in the September 2018 issue of the journal.

Briefly, the manuscript documents a simulation framework for incorporating subject-specific, geometric models and experimental results that are highly resolved in space and time into computational models. This framework provides a means to advance the understanding of the underlying mechanisms of ischemic disease while simultaneously putting in place the computational infrastructure necessary to study and improve ischemia models aimed at reducing diagnostic errors in the clinic. The article can be accessed here

Research Paper published

My research paper titled – Sensitivity of epicardial electrical markers to acute ischemia detection was accepted for publishing in the peer-reviewed journal – Journal of Electrocardiology. The article will be available in print, in the December 2014 issue of the journal.

Briefly, the research focuses on the electrical behavior of the heart during ischemic conditions, which is a precursor to myocardial infarction (heart attack). Specifically, the study evaluated different electrical markers and their ability to detect early onset of acute myocardial ischemia. The  paper reported the findings from the study and can be accessed here.