The Secretome of Atrial Epicardial Adipose Tissue Facilitates Reentrant Arrhythmias by Myocardial Remodeling

Atrial EAT promotes arrhythmias
Atrial EAT promotes arrhythmias

WHAT IS KNOWN?

  1. Obesity is an independent risk factor for sudden cardiac death and atrial fibrillation.
  2. The molecular mechanisms underlying how atrial epicardial adipose tissue (EAT) can induce arrhythmias is not well understood.

WHAT THIS STUDY ADDS

  1. Atrial EAT induces electrophysiological remodeling of myocardium by decreasing electrical coupling, reducing IK1 and depolarizing the maximum diastolic potential.
  2. This results in slowed conduction and increased conduction heterogeneity, depolarized resting potential, which in turn, can facilitate reentrant arrhythmias.

LINK TO THE ARTICLE

Ernault AC, Verkerk AO, Bayer JD, Aras K, Agudo PM, Mohan RA, Veldkamp M, Kawasaki M, van Amersfoorth SCM, Driessen AHG, Efimov IR, de Groot J, Coronel R. The Secretome of Epicardial Adipose Tissue Facilitates Reentrant Arrhythmias by Myocardial RemodelingHeart Rhythm, 2022.