Electrophysiology and Arrhythmogenesis in the Human RVOT

Human RVOT susceptibility to arrhythmias

WHAT IS KNOWN?

  1. Right ventricular outflow tract (RVOT) is a common source of idiopathic ventricular arrhythmias (IVAs). 
  2. However, the mechanisms underlying the RVOT’s unique arrhythmia susceptibility remains not well elucidated due to lack of detailed electrophysiological and molecular studies of human RVOT.

WHAT THE STUDY ADDS

  1. Human RVOT electrophysiology is characterized by shorter APD relative to the right ventricular apical region and drives the transmural dispersion of repolarization and transmural APD dispersion under normal physiological conditions.
  2. Cholinergic stimulation attenuates the arrhythmogenic effects of adrenergic stimulation, including increase in frequency of PVCs and shortening of wavelength.
  3. Arrhythmia in the RV is associated with weak positive spatiotemporal autocorrelation between the epicardial-endocardial arrhythmic wavefronts and reentrant rotors that are relatively more organized in the endocardium.

LINK TO THE ARTICLE

Aras KK, Gams A, Faye NR, Brennan JB, Goldrick K, Li J, Zhong Y, Chiang C, Smith EH, Poston MD, Chivers J, Hanna P, Mori S, Ajijola O, Shivkumar K, Hoover DB, Viventi J, Rogers JA, Bernus O, Efimov IR. Electrophysiology and Arrhythmogenesis of the human right ventricle outflow tract. Circ Arrhythm Electrophysiol. 2022. (Editor’s pick)